Bacterial skin infections, Burns, eczema, seborrheic dermatitis, ecthyma, excoriation, folliculitis, furunculosis, insect bites and stings, lacerations and abrasions, paronychia, pyoderma gangrenosum, skin cysts and abscesses, stasis ulcers and infected skin ulcers, bacterial, fungal or viral superinfection, sycosis barbae, minor surgical wounds, infected contact dermatitis caused by susceptible organisms.
Adult: Apply to the affected area 3-4 times daily.
Child> 1 year: Apply to the affected area 3-4 times daily.
History of hypersensitivity to aminoglycoside; pregnancy; hepatic impairment, skin rash.
Mode of Action
Gentamicin is an aminoglycoside that binds to 30s and 50s ribosomal subunits of susceptible bacteria disrupting protein synthesis, thus rendering the bacterial cell membrane defective.
Concurrent use of neuromuscular blocking agents; myasthenia gravis, parkinsonism; conditions predisposing to ototoxicity and nephrotoxicity; lactation. Monitor plasma concentrations of gentamicin in patients receiving high doses or prolonged courses, in infants, elderly, patients with renal impairment, cystic fibrosis or significant obesity. Monitor auditory and renal functions. Lactation: excreted in breast milk; no adverse effect on nursing infant
Allergic contact dermatitis, Erythema, Pruritus
Synergistic with ampicillin, benzylpenicillin and other ?-lactam antibiotics. Increased risk of severe respiratory depression when used concurrently with anaesthetics or opioids. May reduce renal clearance of zalcitabine and induce hypocalcaemia when used with biphosphonates. Not to be used with agalsidase alfa or beta as it may inhibit alpha-galactosidase activity. Potentially Fatal: Increased incidence of ototoxicity when combined with ethacrynic acid and furosemide. Cephalosporins, ciclosporin, cisplatin, vancomycin, hydrocortisone and indometacin potentiate nephrotoxicity. Potentiates neuromuscular blocking agents.
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.