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ফার্মেসীর জন্য পাইকারি দামে ঔষধ কিনতে রেজিস্টেশন করুন
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Sefety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Eslicar. Please consult your doctor.
CONSULT YOUR DOCTOR
Eslicar may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Eslicar is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby. Eslicar should be used for short periods and sleepiness of the baby should be watched.
UNSAFE
Eslicar may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Eslicar should be used with caution in patients with severe kidney disease. Dose adjustment of Eslicar may be needed. Please consult your doctor. Use of Eslicar is not recommended in patients with severe kidney disease.
CAUTION
Eslicar should be used with caution in patients with liver disease. Dose adjustment of Eslicar may be needed. Please consult your doctor. Use of Eslicar is not recommended in patients with severe liver disease.
Medical Overview
Introduction
Eslicar is a prescription medicine used to treat epilepsy (seizures). It helps to decrease the abnormal and excessive activity of the nerve cells and calms the brain. Eslicar may be taken with or without food, preferably at the same time, each day. Take this medicine in the dose and duration as advised by your doctor. If you have missed a dose, take it as soon as you remember it. Do not skip any doses and finish the full course of treatment even if you feel better. Do not stop taking it abruptly without discussing it with your doctor, as it may increase seizure frequency. Some of the common side effects of this medicine include blurred or double vision, headache, nausea, vomiting, fatigue and diarrhea. It may also cause dizziness and sleepiness, do not drive or do anything that requires mental focus until you know how this medicine affects you. Please consult your doctor if these side effects bother you or do not go away. Your doctor may advice for regular monitoring of sodium levels, as it may reduce the sodium levels in your blood (hyponatremia). Inform your doctor if you are taking oral contraceptive pills as this medicine reduces their levels in the body.
Uses of Eslicar
  • Epilepsy/Seizures
Side effects of Eslicar
Common
  • Sleepiness
  • Blurred vision
  • Nausea
  • Headache
  • Vomiting
  • Double vision
  • Fatigue
  • Balance disorder (loss of balance)
  • Diarrhea
  • Impaired coordination
  • Vertigo
  • Decreased appetite
  • Decreased sodium level in blood
  • Dizziness
How to use Eslicar
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Eslicar may be taken with or without food, but it is better to take it at a fixed time.
How Eslicar works
Eslicar is an anti epileptic medication. It works by blocking the voltage gated sodium channels that stabilizes the hyperexcited nerve cells in the brain. In this way, it treats seizures or fits.
What if you forget to take Eslicar?
If you miss a dose of Eslicar, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
  • Take your medication regularly as directed by your doctor as missing doses can trigger seizures.
  • Do not change the brand of your medicine and make sure that you have sufficient amount of medicine present with you.
  • Some healthy tips to prevent seizures:
  • It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you.
  • Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
  • It may cause a reduction in blood sodium level (hyponatremia). Your doctor may monitor your blood sodium level regularly.
  • Inform your doctor if you notice skin reaction such as rash, skin peeling, and itching while using this medicine.
  • Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency.
Brief Description
Indication
Partial-onset seizures
Administration
May take with or without food
Adult Dose
Partial-Onset Seizures Indicated for partial-onset seizures as monotherapy or adjunctive therapy Initial 400 mg PO qDay For some patients, treatment may be initiated at 800 mg qDay if the need for additional seizure reduction outweighs an increased risk of adverse reactions during initiation Titration & maintenance Increase dose by weekly increments of 400-600 mg, based on clinical response and tolerability Recommended maintenance dose is 800-1600 mg once daily Monotherapy: Consider 800 mg/day maintenance dose in patients unable to tolerate 1200 mg/day Adjunctive therapy: 1600 mg/day should be considered in patients who did not achieve a satisfactory response with 1200 mg/day Hepatic impairment Mild-to-moderate: No dosage adjustment required Severe: Not recommended (not studied)
Child Dose
<18 years: Safety and efficacy not established
Renal Dose
Renal impairment Moderate-to-severe (CrCl <50 mL/min): Reduce the initial, titration, and maintenance doses by 50%; may adjust titration and maintenance doses according to clinical response
Contraindication
Hypersensitivity to the active substance, to other carboxamide derivatives (e.g. carbamazepine, oxcarbazepine) or to any of the excipients. Second or third degree atrioventricular (AV) block.
Mode of Action
Antiepileptic drug; eslicarbazepine acetate is a prodrug that is activated to eslicarbazepine (S-licarbazepine), the major active metabolite of oxcarbazepine. Stabilizes neuronal membranes by blocking Na+ channels; this may inhibit repetitive firing and may decrease the propagation of synaptic impulses; may also increase potassium conductance and modulate the activity of high-voltage activated calcium channels.
Precaution
Suicidal ideation Suicidal ideation and behaviour have been reported in patients treated with anti-epileptic active substances in several indications. A meta-analysis of randomised placebo-controlled trials of anti-epileptic medicinal products has also shown a small increased risk of suicidal ideation and behaviour. Therefore, patients should be monitored for signs of suicidal ideation and behaviours and appropriate treatment should be considered. Patients (and caregivers of patients) should be advised to seek medical advice should signs of suicidal ideation or behaviour emerge. Nervous system disorders Eslicarbazepine acetate has been associated with some central nervous system adverse reactions, such as dizziness and somnolence, which could increase the occurrence of accidental injury. Oral contraceptives Eslicarbazepine acetate may decrease the effectiveness of hormonal contraceptives. Additional non-hormonal forms of contraception are recommended Other warnings and precautions If Eslicarbazepine is to be discontinued it is recommended to withdraw it gradually to minimise the potential of increased seizure frequency. Concomitant use of eslicarbazepine acetate with oxcarbazepine is not recommended because this may cause overexposure to the active metabolites. Hyponatraemia Hyponatraemia has been reported as an adverse reaction in 1.2% of patients treated with Eslicarbazepine. Hyponatraemia is asymptomatic in most cases, however, it may be accompanied by clinical symptoms like worsening of seizures, confusion, decreased consciousness. Frequency of hyponatraemia increased with increasing eslicarbazepine acetate dose. In patients with pre-existing renal disease leading to hyponatraemia, or in patients concomitantly treated with medicinal products which may themselves lead to hyponatraemia (e.g. diuretics, desmopressin, carbamazepine), serum sodium levels should be examined before and during treatment with eslicarbazepine acetate. Furthermore, serum sodium levels should be determined if clinical signs of hyponatraemia occur. Apart from this, sodium levels should be determined during routine laboratory examination. If clinically-relevant hyponatraemia develops, eslicarbazepine acetate should be discontinued. PR interval Prolongations in PR interval have been observed in clinical studies with eslicarbazepine acetate. Caution should be exercised in patients with medical conditions (e.g. low levels of thyroxine, cardiac conduction abnormalities), or when taking concomitant medicinal products known to be associated with PR prolongation. Lactation: Unknown if distributed in human breast milk
Side Effect
>10% Dizziness (20-28%),Somnolence (11-18%),Nausea (10-16%),Headache (13-15%),Diplopia (9-11%) 1-10% Vomiting (6-10%),Fatigue (4-7%),Blurred vision (5-6%),Ataxia (4-6%),Vertigo (2-6%),Diarrhea (2-4%),Tremor (2-4%),Balance disorder (3%),Asthenia (2-3%),Falls (1-3%),Depression (1-3%),Rash (1-3%),Constipation (2%),Abdominal pain (2%),Gait disturbance (2%),UTI (2%),Hyponatremia (2%),Insomnia (2%),Visual impairment (1-2%),Gastritis (1-2%),Peripheral edema (1-2%),Dysarthria (1-2%),Memory impairment (1-2%),Nystagmus (1-2%),Cough (1-2%),Hypertension (1-2%)
Pregnancy Category Note
Pregnancy Limited available data with eslicarbazepine acetate use in pregnant women are insufficient to inform a drug-associated risk of adverse developmental outcomes Advise women of reproductive potential taking eslicarbazepine acetate who are using a contraceptive containing ethinylestradiol or levonorgestrel to use additional or alternative non-hormonal birth control Eslicarbazepine acetate was evaluated in rats and mice for potential adverse impact on fertility of the parental and first generation Lactation Eslicarbazepine is present in human milk; effects of eslicarbazepine acetate on the breastfed infant or on milk production are unknown
ফার্মেসীর জন্য পাইকারি দামে ঔষধ কিনতে রেজিস্টেশন করুন
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Disclaimer
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.