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ফার্মেসীর জন্য পাইকারি দামে ঔষধ কিনতে রেজিস্টেশন করুন
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Sefety Advices
Caution is advised when consuming alcohol with G- Misoprostol. Please consult your doctor.
G- Misoprostol is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
G- Misoprostol should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.
G- Misoprostol may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
G- Misoprostol is safe to use in patients with kidney disease. No dose adjustment of G- Misoprostol is recommended. However, inform your doctor if you have an underlying kidney disease. This medicine may be started with a low dose and then increased with caution by your doctor.
G- Misoprostol is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of G- Misoprostol may not be needed in these patients. Please consult your doctor.
Medical Overview
G- Misoprostol is a medicine used for medical abortion (terminating a pregnancy). It is also used for preventing excessive bleeding after delivery. This medicine acts on the uterus and increases its contraction. G- Misoprostol is given alone or in combination with some other medicine to attain the maximum benefit. It should be taken with food or as your doctor's advice. It should be taken orally, by swallow the tablets whole with a drink of water. If you experience vomiting within 30 minutes of tablet intake, inform your doctor or take another tablet. The medicine may take 24 hours to show its action and you experience bleeding. The most common side effects of this medicine include nausea, Vomiting, Uterine cramps, Diarrhea, Infection following abortion, Uterine bleeding. If these bother you, or appear serious, let your doctor know. There may be ways of reducing or preventing them. Usually, vaginal bleeding may last for 12 days, inform your doctor if it lasts for more than 12 days or you notice severe abdominal pain. Before taking this medicine, tell your doctor if you have ever had an ectopic pregnancy, or you are breastfeeding or using an intrauterine device. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. You must avoid strenuous activity like heavy exercise, running and driving while abortion as it can affect the bleeding. Your doctor may perform an ultrasound or pelvic examination to check for abortion completion.
Uses of G- Misoprostol
  • Medical abortion
  • Post-delivery bleeding
Side effects of G- Misoprostol
  • Menorrhagia (heavy menstrual bleeding)
  • Vomiting
  • Nausea
  • Uterine contractions
  • Diarrhea
  • Stomach cramp
How to use G- Misoprostol
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. G- Misoprostol is to be taken with food.
How G- Misoprostol works
G- Misoprostol increases contractions of the uterus to cause abortion. It can also prevent post-delivery bleeding due to poor contraction of the uterus.
What if you forget to take G- Misoprostol?
If you miss a dose of G- Misoprostol, it is likely that the termination will not be fully effective. Talk to your doctor if you forget to take G- Misoprostol.
Quick Tips
  • G- Misoprostol helps terminate pregnancy when used along with another medicine called mifepristone.
  • It may also be used to prevent excessive bleeding after delivery.
  • For pregnancy termination:
  • Use caution while driving or doing anything that requires concentration as it can cause dizziness and sleepiness.
  • It does not affect fertility. Use contraception to avoid pregnancy.
Brief Description
NSAID-induced ulcers, Termination of pregnancy, Benign gastric and duodenal ulcers
Should be taken with food.
Adult Dose
NSAID-Induced Ulcer Adult: Benign gastric and duodenal ulceration and NSAID associated ulceration: 800 mcg daily (in 2-4 divided doses) with breakfast or main meals and at bedtime; treatment should be continued for at least 4 weeks and may be continued for up to 8 weeks if required. Prophylaxis of NSAID induced gastric and duodenal ulcer: 200 mcg 2-4 times daily taken with NSAID. If this dose cannot be tolerated, a dose of 100 mcg can be used. Misoprostol should be taken for the duration of NSAID therapy Induction of labor: 100 mcg taken orally. If cervical ripening or active labor does not occur, repeated dose of 100- 200 mcg of oral misoprostol is given every 4 hourly until labor is established (as evidenced by a Bishop score of 7 or more). Maximum number of dose is 6. Termination of pregnancy Day 1: 200 mg of mifepristone PO as a single dose under physician supervision Days 2-3: 800 mcg of misoprostol buccally once as a single dose; must be administered a minimum of 24-hr and a maximum of 48-hr following mifeprostone dose on day 1 Days 7-14 Must return for follow-up visit to confirm complete termination has occurred by medical history, clinical examination, hCG testing, or ultrasonographic scan If complete expulsion has not occurred, but the pregnancy is not ongoing, women may be treated with another dose of misoprostol 800 mcg buccally with follow-up in ~7 days Lack of bleeding following treatment usually indicates failure; however, prolonged or heavy bleeding is not proof of a complete abortion Surgical evacuation is recommended to manage ongoing pregnancies after medical abortion Prevention of postpartum haemorrhage: 600 mcg orally immediately following delivery.
Renal Dose
Renal impairment: Use with caution; peak plasma concentration, half-life, and bioavailability may be increased, but it is not clear whether these increases are of clinical relevance
Misoprostol is contraindicated to anyone with a history of allergy to prostaglandins. Women of childbearing potential. Pregnancy and lactation.
Mode of Action
Misoprostol, a synthetic prostaglandin E1 analogue, exerts its antisecretory activity by directly acting on specific prostaglandin receptors found on the surface of gastric parietal cells. It exerts its protective effects on the mucosa by replacing the prostaglandins consumed during prostaglandin-inhibiting therapies e.g. NSAIDs.
In case of prevention and treatment of NSAID induced gastric and duodenal ulcer: Misoprostol is contraindicated in women who are pregnant, and should not be used in women of child bearing potential unless the patient requires NSAID therapy. Women of child bearing potential should be told that they must not be pregnant when Misoprostol therapy is initiated and they must use an effective contraception method while taking misoprostol. Conditions where hypotension might precipitate severe complications e.g. cerebrovascular or CV disease. Inflammatory bowel disease. Patients prone to dehydration. Elderly. Renal impairment. Lactation: Drug is rapidly metabolized in mother to misoprostol acid, which is biologically active and is excreted in breast milk; although no published reports of adverse effects of misoprostol in breast-feeding infants exist, caution should be exercised when misoprostol is administered to breastfeeding women
Side Effect
>10% Diarrhea (14-40%),Abdominal pain (13-20%) 1-10% Headache (2%) Frequency Not Defined Anaphylaxis,Anemia,Cardiac dysrhythmia,Chest pain,Flatulence,Gastrointestinal hemorrhage,Hearing loss,Myocardial infarction,Nausea Rupture of uterus,Thromboembolic disorder
May increase effects of oxytocin. Increased risk of misoprostol-induced diarrhoea with magnesium-containing antacids.
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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.