CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Palnox. Please consult your doctor.
SAFE IF PRESCRIBED
Palnox is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Palnox is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Palnox may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Palnox is safe to use in patients with kidney disease. No dose adjustment of Palnox is recommended.
SAFE IF PRESCRIBED
Palnox is safe to use in patients with liver disease. No dose adjustment of Palnox is recommended.
Palnox is an antiemetic medicine commonly used to control nausea and vomiting due to certain medical conditions like stomach upset. It is also used to prevent nausea and vomiting caused due to any surgery, cancer drug therapy or radiotherapy. Palnox will not relieve other side effects associated with cancer treatments. It also has little effect on vomiting caused by motion sickness. You should take this medicine in the dose and duration advised by your doctor. But, it is better to take this medicine at a fixed time. Remember you should not stop taking the medication suddenly without talking to your doctor. In case you vomit within one hour of taking a dose then take another dose and avoid heavy meals throughout the day. The most common side effects of taking this medicine include headache and constipation. Dizziness and sleepiness may also occur, so do not drive or do anything that requires mental focus until you know how this medicine affects you. These symptoms should disappear when you stop taking the medicine. However, if these bother you or do not go away, consult your doctor who may be able to suggest ways of preventing or reducing them. Before taking this medicine, tell your doctor if you have heart or liver problems or a blockage in your stomach or intestines. Also, tell your doctor about any other medicine you are using, especially medicines to treat epilepsy, heart problems, cancer and depression. These may affect, or be affected by, this medicine. If you are pregnant or breastfeeding, ask for advice from your healthcare team.
Uses of Palnox
Side effects of Palnox
How to use Palnox
Take this medicine in the dose and duration as advised by your doctor. Do not handle the tablets with wet hands. Put it in your mouth but do not swallow it. Palnox may be taken with or without food, but it is better to take it at a fixed time.
How Palnox works
Palnox is an antiemetic medication. It works by blocking the action of a chemical messenger (serotonin) in the brain that may cause nausea and vomiting during anti-cancer treatment (chemotherapy) or after surgery.
What if you forget to take Palnox?
If you miss a dose of Palnox, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
- You have been prescribed EME OD Tablet MD for prevention of nausea and vomiting caused after surgery or due to chemotherapy and radiotherapy.
- Unlike some other nausea medicines, the side effects for EME OD Tablet MD are relatively mild.
- It is fast-acting and starts working within 30 minutes.
- If you vomit within one hour of taking a dose, take another dose.
- Avoid heavy meals and try eating small nourishing snacks throughout the day. Also, sip water regularly to help avoid dehydration.
Chemotherapy-induced nausea and vomiting, Postoperative nausea and vomiting
Reconstitution: Physically and chemically stable at concentrations of 5 and 30 mcg/ml in glucose 5%, sodium chloride 0.9%, glucose 5% in lactated Ringer's for at least 48 hr at room temperature, exposed to light and for 14 days under refridgeration. IV Administration Flush IV line with NS before and after administration CINV: give IVP evenly over 30 sec (adults) or 15 min (children) PONV: IVP over 10 sec
Prevention of Chemotherapy-induced Nausea & Vomiting Intravenous Adult: 0.25 mg IV as a single dose. To be given over 30 sec and 30 minutes before chemotherapy. Do not repeat within 7 days. Oral Alternatively 0.5 mg tablet/capsule approximately 1 hour before the start of chemotherapy. Then 0.5 mg tablet once daily. Prevention of Postoperative Nausea & Vomiting Adult: 0.075 mg IV as a single dose immediately before induction of anaesthesia. Hepatic impairment: Dose adjustment not necessary
Prevention of Postoperative Nausea & Vomiting <18 years: Safety and efficacy not established Prevention of Chemotherapy-induced Nausea & Vomiting <1 month: Safety and efficacy not established 1 month to 17 years: 20 mcg/kg IV infused over 15 minutes x1, beginning 30 minutes before chemotherapy; not to exceed 1.5 mg/dose
Renal impairment: Dose adjustment not necessary
History of hypersensitivity.
Mode of Action
Palonosetron is a selective 5-HT3 antagonist that is used in the prevention of acute and delayed emesis in emetogenic cancer chemotherapy regimens.
Patients with intestinal obstruction or ileus. Rapid inj may lead to temporary visual changes e.g. blurred vision. Patients who have or may develop prolonged QT intervals. Safety and efficacy not established in children <18 yr. Counsel patients who handle skilled tasks e.g. driving may be impaired. Lactation: unknown, discontinue drug or do not nurse
1-10% Prolonged QT interval (up to 5% ),Anxiety,Dizziness,Headache,Weakness,Constipation,Diarrhea,Prutitus,Hyperkalemia,LFT's increased <1% First degree atrioventricular block,Second degree atrioventricular block Frequency Not Defined Immune hypersensitivity reaction (very rare),Seizure
May have additive effect on prolonging QT with drugs e.g. moxifloxacin, erythromycin, antipsychotics and TCAs.
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.