Introduction
Hytrain belongs to a class of medicines called as alpha-blocker. It is used to treat high blood pressure and lower your risk of having a heart attack or stroke. It may also be used to treat heart failure and mild enlargement of the prostate gland in men (benign prostatic hyperplasia).
Hytrain may be prescribed alone or in combination with other medicines. It can be taken with or without food. The dose will depend on your condition and how you respond to the medicine. Follow the advice of your doctor on what is right for you. You need to use this medicine regularly to get the most benefit from it so keep taking it even if you feel well. High blood pressure does not usually have symptoms. If you stop taking it, your blood pressure may rise and put you at risk of heart attack or stroke. You may need to take it for the rest of your life.
The most common side effects of this medicine include dizziness, drowsiness, headache, nausea and unusual beating of the heart (palpitations). Most side effects disappear when you get used to the medicine. If they bother you or won't go away, talk to your doctor. To lower the chance of dizziness, rise slowly if you have been sitting or lying down. It may also cause your blood pressure to go too low. Some side effects may be serious and need urgent medical attention. Your doctor may be able to help with ways of preventing or reducing side effects.
If you are pregnant, thinking about becoming pregnant or breastfeeding, ask your doctor before using this medicine. Also talk to your doctor before taking it if have heart failure, liver disease or kidney disease and if you are having eye surgery for a cataract. Your blood pressure will need to be checked regularly while using this medicine.
Uses of Hytrain
- Hypertension (high blood pressure)
- Benign prostatic hyperplasia
Side effects of Hytrain
Common
- Dizziness
- Headache
- Drowsiness
- Low energy
- Weakness
- Palpitations
- Nausea
How to use Hytrain
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Hytrain may be taken with or without food, but it is better to take it at a fixed time.
How Hytrain works
Hytrain is an alpha-blocker. It lowers blood pressure by relaxing blood vessels. It also relaxes the muscles around the bladder exit and prostate, which makes it easier to urinate.
What if you forget to take Hytrain?
If you miss a dose of Hytrain, skip it and continue with your normal schedule. Do not double the dose.
Indication
Hypertension, Benign prostatic hyperplasia
Administration
May be taken with or without food. Give first dose and subsequent increases at bedtime to avoid syncope
Adult Dose
Oral
Hypertension
Adult: Initially, 1 mg at bedtime, gradually increased at 7-day intervals according to response. Maintenance: 2-10 mg once daily.
Max: 20 mg/day in 1 or 2 divided doses.
Elderly: Initial: 0.5 mg at bed time and titrate to response
Benign prostatic hyperplasia
Adult: Initially, 1 mg at bedtime gradually increased at 7-day intervals according to response. Maintenance: 5-10 mg once daily.
Hepatic impairment: Use with caution
Contraindication
Hypersensitivity to quinazoline derivatives.
Mode of Action
Terazosin is an alpha1-adrenoceptor antagonist which blocks peripheral postsynaptic receptors resulting to decreased arterial tone. It relaxes smooth muscle of the bladder neck causing a reduction of bladder outlet obstruction.
Precaution
Prostate cancer should be ruled out before starting therapy. Patient w/ history of micturition syncope, prostate cancer, angina. Elderly. Pregnancy and lactation. Patient Counselling May impair ability to drive, operate machinery or engage in hazardous activities. Monitoring Parameters Monitor BP regularly.
Lactation: Not known if excreted into breast milk; use caution
Side Effect
>10%
Dizziness (10-20%),Asthenia (2-13%)
1-10%
Hypotension (3-7%),Rhinitis/nasal congestion (2-6%),Lightheadedness (3-5%),Somnolence (3-5%),Palpitation (4%),Nausea (2-4%),Edema (3%),Sinusitis (3%),Dyspnea (2-3%),Fatigue (2.5%),Headache (2.5%),Back pain (2.4%),Flulike syndrome (2.4%),Tachycardia (2%),Amblyopia (1-2%),Blurred vision (1-2%),Impotence (1-2%),Syncope (1%)
Interaction
Concomitant admin w/ phosphodiesterase-5 (PDE-5) inhibitors (e.g. sildenafil) can result in additive BP lowering effects and symptomatic hypotension. Possible significant hypotension when admin w/ other antihypertensive agents e.g. verapamil.