Permival may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Permival may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Permival is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Permival may cause side effects which could affect your ability to drive. As Permival may affect your alertness which may affect your ability to drive.
CONSULT YOUR DOCTOR
There is limited information available on the use of Permival in patients with kidney disease. Please consult your doctor.
Permival should be used with caution in patients with liver disease. Dose adjustment of Permival may be needed. Please consult your doctor. Inform your doctor if you develop any signs and symptoms of jaundice while taking this medicine. Use of Permival is not recommended in patients with severe liver disease.
Permival is a combination of two medicines used in the treatment of schizophrenia, a mental disorder that can result in hallucinations or delusions. It alters the thoughts and elevates the mood, improving the person’s ability to think, feel and behave. Permival may be taken with or without food, preferably at the same time each day. Take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember it. Do not skip any doses and finish the full course of treatment even if you feel better. It is important that this medication is not stopped suddenly without talking to your doctor as it may worsen your symptoms. Some common side effects of this medicine include dry mouth, constipation, urinary retention, blurred vision, increased heart rate, muscle rigidity, restlessness, and tremor. Initially, this medicine may cause a sudden drop in blood pressure when you change positions, rise slowly if you have been sitting or lying down. It may also cause dizziness and sleepiness, do not drive or do anything that requires mental focus until you know how this medicine affects you. Before taking it, inform your doctor if you are suffering from thyroid or kidney disease, epilepsy, Parkinson's disease, glaucoma, or any heart disease. You should not take this medicine if you are under the influence of alcohol or any sleep-inducing, cough, and/ or allergy medication. This medicine can also lead to weight gain, eat a healthy balanced diet, avoid snacking with high-calorie food, and exercise regularly.
Uses of Permival
Side effects of Permival
- Dryness in mouth
- Weight gain
- Orthostatic hypotension (sudden lowering of blood pressure on standing)
- Urinary retention
- Increased prolactin level in blood
- Blurred vision
- Increased heart rate
- Muscle stiffness
How to use Permival
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Permival may be taken with or without food, but it is better to take it at a fixed time.
How Permival works
Permival is a combination of two medicines: Fluphenazine and Nortriptyline which have anxiety-lowering and mood-elevating effects. Fluphenazine is a typical antipsychotic. It works by blocking the action of dopamine, a chemical messenger in the brain that affects thoughts and mood. Nortriptyline is a tricyclic antidepressant which increases the levels of chemical messengers in the brain that help in regulating the mood and treat depression.
- Tripnor 0.5 mg/10 mg Tablet helps treat anxiety and depression.
- Use caution while driving or doing anything that requires concentration as Tripnor 0.5 mg/10 mg Tablet can cause dizziness and sleepiness.
- Avoid drinking alcohol while taking this medicine because it can make drowsiness worse.
- It can cause changes in your blood sugar levels. Monitor your blood sugar regularly.
- Inform your doctor if you have liver disease, thyroid disorder, severe heart disease, or a urinary disorder.
- Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
- Let your doctor know you are taking Tripnor 0.5 mg/10 mg Tablet before undergoing any surgical procedure.
Headache, Depression, Anxiety, Emotional disturbance, Tension, Fatigue, Sleep disorder, Bodyache, Gastric problems
Adult: 1 tablet 2 to 3 times daily.
Child: Not recommended.
Patients with suspected or established subcortical brain damage, in patients receiving large doses of hypnotics, and in comatose or severely depressed states. The presence of blood dyscrasia or liver damage precludes the use of fluphenazine hydrochloride. Fluphenazine hydrochloride is contraindicated in patients who have shown hypersensitivity to fluphenazine; cross sensitivity to phenothiazine derivatives may occur.
Mode of Action
Fluphenazine blocks postsynaptic dopamine D1 and D2 receptors in the mesolimbic system and decreases the release of hypothalamic and hypophyseal hormones. It reduces aggressiveness with disappearance of hallucinations and delusions. Nortriptyline, a dibenzocycloheptadiene tricyclic antidepressant, is the primary active metabolite of amitriptyline. It increases synaptic concentration of serotonin and/or norepinephrine in the CNS by blocking the neuronal reuptake of norepinephrine and serotonin.
Patients with glaucoma, prostate enlargement, cardiac failure and myocardial infarction. The drug may impair alertness and abilities to drive a car or operating machinery. Because of the possibility of cross-sensitivity, fluphenazine hydrochloride should be used cautiously in patients who have developed cholestatic jaundice, dermatoses or other allergic reactions to phenothiazine derivatives. Psychotic patients on large doses of a phenothiazine drug who are undergoing surgery should be watched carefully for possible hypotensive phenomena. Moreover, it should be remembered that reduced amounts of anesthetics or central nervous system depressants may be necessary. The effects of atropine may be potentiated in some patients receiving fluphenazine because of added anticholinergic effects.
Dryness of mouth, drowsiness, constipation, tachycardia, nasal congestion, blurred vision and excitement.
Reduces antihypertensive effects of guanethidine, methyldopa and clonidine. Lithium toxicity. Reduced bioavailability with antacids. Increased risk of arrhythmia when used with drugs that prolong QT interval. May cause electrolyte disturbance when used with diuretics. Potentially Fatal: Additive CNS depressant effects with alcohol, barbiturates, hypnotics, sedatives, opiates and antihistamines.
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.