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ফার্মেসীর জন্য পাইকারি দামে ঔষধ কিনতে রেজিস্টেশন করুন
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Sefety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Sandostatin SC. Please consult your doctor.
SAFE IF PRESCRIBED
Sandostatin SC is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Sandostatin SC is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
SAFE
Sandostatin SC does not usually affect your ability to drive.
SAFE IF PRESCRIBED
Sandostatin SC is safe to use in patients with kidney disease. No dose adjustment of Sandostatin SC is recommended.
CAUTION
Sandostatin SC should be used with caution in patients with liver disease. Dose adjustment of Sandostatin SC may be needed. Please consult your doctor.
Medical Overview
Introduction
Sandostatin SC is used in the treatment of acromegaly, carcinoid tumors, and bleeding esophageal varices. It is also used to prevent complications following surgery of the pancreas. Sandostatin SC is generally given by a healthcare professional. You should not self-administer this medicine at home. Your doctor will decide the dose and how often you should take them. You should use it regularly to get the most benefit from the medicine. Do not stop using the medicine even if you feel better unless the doctor tells you so. Using this medicine may cause few common side effects such as diarrhea, abdominal pain, nausea, constipation, flatulence, and headache. Let your doctor know if any of these side effects do not go away or get worse. Before using this medicine, inform your doctor if you have problems with your liver. You should also tell your doctor all the other medicines you are taking.
Uses of Sandostatin SC
  • Acromegaly
  • Carcinoid tumours
  • Bleeding esophageal varices
Side effects of Sandostatin SC
Common
  • Diarrhea
  • Abdominal pain
  • Nausea
  • Constipation
  • Flatulence
  • Headache
  • Increased glucose level in blood
  • Injection site reaction
How to use Sandostatin SC
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Sandostatin SC works
Sandostatin SC is a similar to somatostatin, a substance normally found in the human body which inhibits the effects of certain hormones such as growth hormone. It also lowers the bleeding from the food pipe by constricting (narrowing) the blood vessels.
What if you forget to take Sandostatin SC?
If you miss a dose of Sandostatin SC, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
  • Sandostatin SC helps treat acromegaly and certain hormone-producing tumors of stomach, liver, and pancreas.
  • It is given as an injection under the skin or into a vein.
  • It may temporarily cause pain at the site of injection. You can relieve this by gently rubbing the site of injection for a few seconds afterwards.
  • When used long term, your doctor may monitor your thyroid function, gallbladder function, liver function and vitamin b12 levels regularly.
  • Inform your doctor if you are taking medicines to control your blood pressure or if you are diabetic.
  • Women who do not wish to conceive should practice an effective method for contraception while taking this medication.
Brief Description
Indication
Acromegaly, Variceal haemorrhage, Secretory neoplasms, Following pancreatic surgery, HIV-associated diarrhoea
Administration
IV Preparation Common diluent: 50-100 ?g/50 mL NS Common diluent for continuous IV infusion: 1200 ?g/250 mL NS Minimum volume: 50 mL NS IV/IM Administration IM Administer suspension (depot injection) immediately after reconstitution; inject into gluteal muscle, avoiding deltoid IV IV administration may be IVP, IVPB, or continuous infusion Regular injection only: IVP should be administered undiluted over 3 minutes IVPB: Administer over 15-30 minutes Continuous infusion: 25-50 ?g/hr for treatment of esophageal variceal bleeding
Adult Dose
Acromegaly Solution: 50 mcg SC q8hr initially; titrate up to 500 mcg SC q8hr if necessary; after successful treatment with solution for 2 weeks, initiate treatment with suspension (depot injection) Suspension (depot injection): 20 mg IM (gluteal) every 4 weeks for 3 months; titrate up or down to 10-30 mg IM every 4 weeks, depending on response; not to exceed 40 mg, as follows Symptoms controlled: If GH < 1 ng/mL and IGF-1 normal, decrease dose to 10 mg IM every 4 weeks; if GH < 2.5 ng/mL and IGF-1 normal, maintain dose at 20 mg IM every 4 weeks Symptoms uncontrolled: If GH > 2.5 ng/mL or IGF-I elevated, increase dose to 30 mg IM every 4 weeks; if symptoms persist, increase to 40 mg IM Carcinoid Tumor Solution: 100-600 mcg/day SC divided q6-12hr; may titrate to 1500 mcg/day; after successful treatment with solution for 2 weeks, initiate treatment with suspension (depot injection) Suspension (depot injection): 20 mg IM every 4 weeks if regular injection well tolerated Subcutaneous Prophylaxis of complications following pancreatic surgery Adult: 100 mcg tid of a rapid-acting preparation given for 7 consecutive days, starting at least 1 hr before operation. HIV-associated diarrhoea Adult: Initial dose 100 mcg tid. If symptoms are not controlled after 1 wk, increase dose to 500 mcg tid. Intravenous Variceal haemorrhage in patients with cirrhosis Adult: As continuous IV infusion: 25 mcg/hr for 48 hr (up to 5 days in patients at high risk of re-bleeding). Hepatic impairment: Cirrhosis, 10 mg IM every 4 weeks initially, then titrate to effect
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment: Without dialysis, dose adjustment not necessary; with dialysis, 10 mg IM every 4 weeks initially, then titrate to effect
Contraindication
Hypersensitivity.
Mode of Action
Octreotide is a synthetic analogue of somatostatin which acts by suppressing basal and stimulated secretion of growth hormone (GH). It also suppresses LH response to gonadotrophin-releasing hormone and reduces the secretion of gastrin, vasoactive intestinal peptide (VIP), insulin, glucagon, secretin, motilin and pancreatic polypeptide.
Precaution
Renal disease; risk of gall bladder disease; DM; hypothyroidism. Pregnancy, lactation, children, elderly. Monitor levels of vitamin B12 during long term therapy. Lactation: Whether octreotide crosses into breast milk is not known; avoid giving to lactating women
Side Effect
>10% Gallbladder problems (>60%): Decreased gallbladder contractility, gallstones, cholecystitis, cholestatic hepatitis,Dysglycemia (25%),Hypothyroidism (25%),Bradycardia (25%) 1-10% ECG changes (10%),Arrhythmia (9%),Pancreatitis,Upper respiratory tract infection,Fatigue,Headache,Malaise,Rash,Diarrhea,Nausea,Vomiting,Pain at injection site,Joint pain,Blurred vision
Interaction
Dosage adjustment of concurrent therapy may be necessary with calcium channel blockers, oral hypoglycaemics, ?-blockers, diuretics. May increase concentration of bromocriptine. Potentially Fatal: Requirements of insulin may be reduced requiring careful blood-glucose monitoring. Reduction in ciclosporin bioavailability and efficacy.
ফার্মেসীর জন্য পাইকারি দামে ঔষধ কিনতে রেজিস্টেশন করুন
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Disclaimer
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.