Introduction
Zocil 50 is used in the treatment of pain in legs due to insufficient blood flow (intermittent claudication). It also helps in reducing cramping, numbness, or weakness in the legs that occurs on walking in such patients.
Zocil 50 should be taken regularly as advised by the doctor. You should take it on an empty stomach and at a fixed time. This medicine should not be stopped abruptly without consulting the doctor.
It may cause side effects like headache, edema, nausea, diarrhea, dizziness and chest pain. Use of this medicine may increase your risk of bleeding. Let your doctor know immediately if you see pinpoint rash or blood in your vomits, urine, or stool.
This medicine may not be suitable for some people. You must inform the doctor if you are suffering from any liver or kidney disease. Also, let your doctor know about all the other medications that you are using regularly. This medicine is not usually recommended during pregnancy or breastfeeding, so always consult your doctor before taking it.
Uses of Zocil 50
- Intermittent claudication
Side effects of Zocil 50
Common
- Headache
- Palpitations
- Abnormal stool
- Diarrhea
- Dizziness
- Chest pain
- Loss of appetite
- Bleeding
- Rash
How to use Zocil 50
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zocil 50 is to be taken empty stomach.
How Zocil 50 works
Zocil 50 widens the blood vessels and decreases the stickiness of the platelets, thereby increasing the blood flow to the lower limbs.
What if you forget to take Zocil 50?
If you miss a dose of Zocil 50, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Indication
Peripheral vascular disease, Intermittent claudication
Administration
Should be taken on an empty stomach. Take at least ½ hr before or 2 hr after meals.
Adult Dose
Oral
Peripheral vascular disease
Adult: 100 mg bid.
May reduce dose in patients taking enzyme inhibitors concurrently.
Hepatic Impairment
Moderate to severe: Use caution
Renal Dose
Renal Impairment
CrCl< 25 mL/min: Use caution
Contraindication
Heart failure; known predisposition to bleeding; history of ventricular arrhythmias; QT interval prolongation; severe renal impairment; moderate to severe hepatic impairment.
Mode of Action
Cilostazol is a reversible, selective inhibitor of phosphodiesterase-III (PDE-III), thereby suppressing cyclic adenosine monophosphate (cAMP) degradation. Increase in cAMP in platelets and blood vessels leads to inhibition of platelet aggregation and vasodilation. Cilostazol also inhibits adenosine uptake into cells, which augments the cAMP-elevating effect of PDE-III inhibition.
Precaution
Congestive heart disease. Concurrent therapy with clopidogrel has not been studied for safety or efficacy. Pregnancy and lactation.
Lactation: Excretion in milk unknown; not recommended
Side Effect
>10%
Headache (27-34%),Diarrhea (12-19%),Abnormal stools (12-15%),Infection (10-14%),Rhinitis (7-12%),Pharyngitis (7-10%)
1-10%
Dizziness (9-10%),Palpitations (5-10%),Peripheral edema (7-9%),Back pain (6-7%),Dyspepsia (6%),Abdominal pain (4-5%),Tachycardia (4%),Increased cough (3-4%),Myalgia (2-3%),Atrial fibrillation (<2%),CHF (<2%),MI (<2%),Hematemesis (<2%),Ecchymosis (<2%),Blood in eye (<2%),Epistaxis (<2%),Hemoptysis (<2%),Nausea
Frequency Not Defined
Decreased platelet aggregation,Agranulocytosis,Aplastic anemia,Leukopenia,Thrombocytopenia,Stevens-Johnson syndrome
Pregnancy Category Note
Pregnancy category: C
Lactation: Excretion in milk unknown; not recommended
Interaction
Co-admin with drugs that affect CYP3A4 (erythromycin, other macrolides, diltiazem) or CYP2C19 (omeprazole) may influence the pharmacokinetics of cilostazol.