Introduction
Trubid DS is an antibiotic medicine used to treat bacterial infections in your body. It is effective in infections of the throat, ears, urinary tract, skin, and soft tissues. It kills bacteria, which helps to improve your symptoms and cure the infection.
Trubid DS may be taken with or without food. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you to remember to take it. The dose will depend on what you are being treated for, but you should always complete a full course of this antibiotic as prescribed by your doctor. Do not stop taking it until you have finished, even when you feel better. If you stop taking it early, some bacteria may survive and the infection may come back. It will not work for viral infections such as flu or the common cold. Using any antibiotic when you do not need it can make it less effective for future infections.
The most common side effects of this medicine include rash, vomiting, stomach pain, nausea, and diarrhea. These are usually mild but let your doctor know if they bother you or last more than a few days.
Before using it, you should tell your doctor if you are allergic to any antibiotics or have any kidney or liver problems. You should also let your doctor know all other medicines you are taking as they may affect, or be affected by this medicine. Pregnant and breastfeeding mothers should consult their doctor before using it.
Side effects of Trubid DS
Common
- Rash
- Vomiting
- Allergic reaction
- Stomach pain
- Nausea
- Diarrhea
How to use Trubid DS
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Trubid DS may be taken with or without food, but it is better to take it at a fixed time.
How Trubid DS works
Trubid DS is an antibiotic. It kills bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.
Indication
Pharyngitis, Susceptible infections, Sore throat, Tonsillitis, Urinary tract infection, Reproductive tract infection, Skin infections
Administration
May be taken with or without food. May be taken w/ meals to reduce GI discomfort.
Adult Dose
Oral
Tonsillitis; Skin and skin structure infections; Streptococcal pharyngitis; Urinary tract infections
Adult: 1-2 g daily as a single or in 2 divided doses.
Hepatic impairment: No dosage adjustment needed.
Child Dose
Oral
Tonsillitis; Skin and skin structure infections; Streptococcal pharyngitis; Urinary tract infections
Child: >6 yr <40 kg: 30-50 mg/kg daily as a single or in 2 divided doses, up to 100 mg/kg daily.
Renal Dose
Renal impairment:
CrCl (ml/min)
26-50 0.5-1 g bid.
11-25 0.5-1 g once daily.
<10 0.5-1 g every 36 hr.
Contraindication
Hypersensitivity to cephalosporins.
Mode of Action
Cefadroxil binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. Cefadroxil is not active against Proteus, Pseudomonas, Enterobacter, Morganella, Serratia and Listeria monocytogenes.
Precaution
Impaired renal function; pregnancy and lactation.
Lactation: enters breast milk; use with caution
Side Effect
1-10%
Diarrhea
<1%
Abdominal pain,Dyspepsia,Nausea,Vomiting,Rash,Urticaria,Pseudomembranous colitis,Stevens-Johnson syndrome,Anaphylaxis,Transaminases increased,Neutropenia
Potentially Fatal: Anaphylactic reaction; pseudomembranous colitis.
Pregnancy Category Note
Pregnancy Category: B
Lactation: enters breast milk; use with caution
Interaction
Concomitant use w/ bacteriostatic antibiotics (e.g. tetracycline, erythromycin, sulfonamides, chloramphenicol) may cause antagonistic effect. May potentiate nephrotoxic effects of aminoglycoside antibiotics, polymyxin B, colistin or high-dose loop diuretics. May enhance the anticoagulant effect of vit K antagonists. May diminish the therapeutic effect of BCG, typhoid vaccine and Na picosulfate. May attenuate the effect of oral contraceptives. Increased serum concentration w/ probenecid. Reduced bioavailability w/ colestyramine.