Introduction
Survec belongs to a group of medicines called muscle relaxants. It is used along with general anesthesia or sedatives to provide skeletal muscle relaxation during surgical procedures. It is also used to facilitate emergency airway management in patients in intensive care.
Survec is administered by a healthcare professional. You should not self-administer this medicine at home. The dose and duration will depend on what you are taking it for and how well it helps your symptoms.
The most common side effects of this medicine include injection site reactions such as pain, redness, and swelling. Long-term use of this medicine may cause skeletal muscle weakness or even paralysis. You should let your doctor know if the side effects bother you. Your doctor may be able to suggest ways of preventing or reducing the symptoms.
Before using it, to make sure it is safe for you, you should let your doctor know if you have any other medical conditions or disorders. You should also tell your doctor all the other medicines you are using or taking. Pregnant and breastfeeding women should consult their doctors before using this medicine.
Uses of Survec
- Skeletal mucle relaxation during surgery
Side effects of Survec
Common
- Skin rash
- Increased saliva production
- Injection site reactions (pain, swelling, redness)
- High blood pressure
How to use Survec
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Survec works
Survec relaxes the muscles by blocking the impulses from the nerves.
Indication
General anaesthesia, Skeletal muscle relaxation
Adult Dose
Intravenous
Muscle relaxant in general anaesthesia; Facilitate endotracheal intubation; Facilitate mechanical ventilation in intensive care
Adult: Initially, 80-100 mcg/kg by inj. Maintenance: 20-30 mcg/kg by inj or as continuous infusion at 0.8-1.4 mcg/kg/min.
Surgical procedures after intubation w/ suxamethonium: 30-50 mcg/kg.
Caesarean section: <100 mcg/kg.
Surgery under halothane and neurolept anaesth: Initially, 150-300 mcg/kg.
Child Dose
Intravenous
Muscle relaxant in general anaesthesia; Facilitate endotracheal intubation; Facilitate mechanical ventilation in intensive care
Child: <4 mth Initial test dose: 10-20 mcg/kg, w/ increments according to response;
> 4 month: 80-100 mcg/kg by inj. Maintenance: 20-30 mcg/kg by inj or as continuous infusion at 0.8-1.4 mcg/kg/min.
Neonatal surgery: <100 mcg/kg.
Contraindication
Hypersensitivity to vecuronium or bromide.
Mode of Action
Vecuronium bromide inhibits depolarisation by blocking acetylcholine from binding to receptors on motor endplate.
Precaution
Patient w/ CV disease, oedema, neuromuscular disease, previous poliomyelitis, burn injury, severe electrolyte disturbances, altered blood pH, dehydration; obese patient. Hepatic and renal impairment. Childn. Pregnancy and lactation. Monitoring Parameters Monitor BP, heart rate; peripheral nerve stimulation.
Side Effect
Skeletal muscle weakness or paralysis, resp insufficiency or apnoea, bronchospasm, hypotension, tachycardia, acute urticaria, erythema, minimal induration, redness, itching, CV effects (e.g. changes in heart rate, cardiac index), myopathy.
Potentially Fatal: Anaphylaxis.
Interaction
Increases neuromuscular blockade with volatile anaesthetic agents (halothane, ether, enflurane, isoflurane, methoxyflurane, propofol and cyclopropane), fentanyl, other non-depolarising muscle relaxants, prior admin of succinylcholine, tetracyclines, polymyxins, diuretics, thiamine, MAOIs, bacitracin, colistin, sodium colistimethate, acylaminopenicillins, aminoglycoside antibiotics, high dose metronidazole, protamine, beta-adrenergic blocking agents, calcium antagonists e.g. verapamil, and Mg. Decreased neuromuscular blockade with anticholinesterases, prior chronic admin of corticosteroids, phenytoin, carbamazepine, noradrenaline, azathioprine, theophylline, calcium chloride.