CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Steron. Please consult your doctor.
CONSULT YOUR DOCTOR
Steron may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Steron is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Steron does not usually affect your ability to drive.
SAFE IF PRESCRIBED
Steron is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Steron may not be needed in these patients. Please consult your doctor. Regular monitoring of kidney function tests and other blood tests is advisable while you are taking Steron.
Steron should be used with caution in patients with liver disease. Dose adjustment of Steron may be needed. Please consult your doctor.
Steron belongs to a group of medicines called steroids. It is used in the treatment of various diseases and conditions (such as severe allergic reactions, asthma, rheumatic disorder, skin disorders and eye disorders). Steron provides relief from swelling, redness, pain, and itching in the affected area by preventing the release of substances that cause inflammation. It is given by a healthcare professional and should not be self-administered. You need to use it regularly to get the maximum benefit of the medicine. The most common side effects of this medicine include injection site reactions (pain, swelling, redness) and mood changes. If you experience such symptoms that persist or worsen, or any other symptoms which you think may be due to the medicine, let your doctor know. Taking Steron can make it harder for you to fight off infections. Tell your doctor if you have any signs of infection such as a fever or sore throat. Before taking the medicine, let your doctor know all the other medicines you are taking. Pregnant and breastfeeding mothers should ask the advice of their doctors before taking this medicine.
Uses of Steron
- Allergic conditions
- Severe allergic reactions
- Rheumatic disorder
- Skin disorders
- Eye disorders
- Nephrotic syndrome
Side effects of Steron
- Injection site reactions (pain, swelling, redness)
- Mood changes
How to use Steron
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Steron works
Steron is a steroid which works by blocking the production of certain chemical messengers in the body that cause inflammation (redness and swelling) and allergies.
- Steron helps treat inflammation, severe allergies, flare-ups of ongoing illnesses, and many other medical problems that require either reduction of inflammation or suppression of the immune system.
- Do not use it more often or for longer than advised by your doctor.
- Steron can make it harder for you to fight off infections. Notify your doctor if you have any signs of infection such as a fever or sore throat.
- Side effects such as mood changes or stomach problems can happen when you start taking Steron. Inform your doctor if this bothers you.
- Do not stop taking Steron suddenly without talking to your doctor first as it may worsen your symptoms.
Ulcerative colitis, Rheumatoid arthritis, Multiple sclerosis, Nausea and vomiting, Multiple myeloma, Cerebral oedema, Shock, Inflammatory joint diseases, Idiopathic thrombocytopenic purpura, Dental surgery, Allergic anaphylactic shock, Brain tumors, Status asthmaticus
IV Preparation Standard diluent: 4 mg/50 mL D5W or 10 mg/50 mL D5W Minimum volume: 50 mL D5W IV/IM Administration Dexamethasone sodium phosphate: Administered by IV push, continuous or intermittent IV infusion, or IM
Dexamethasone sodium phosphate injection, – For intravenous, intramuscular, intra-articular, intralesional, and soft tissue injection. Dexamethasone can be given parenterally at doses of 0.5-20 mg daily, either as a single IV/IM injection or by IV infusion. Cerebral Edema 10 mg IV, then 4 mg IM q6hr until clinical improvement is observed; may be reduced after 2-4 days and gradually discontinued over 5-7 days Shock 1-6 mg/kg IV once or 40 mg IV q2-6hr PRN Alternative: 20 mg IV, then 3 mg/kg/day by continuous IV infusion High-dose treatment not to be continued beyond 48-72 hours
Airway Edema 0.5-2 mg/kg/day IV/IM divided q6hr, starting 24 hours before extubation and continued for 4-6 doses afterward Croup 0.6 mg/kg IV/IM once; not to exceed 16 mg Inflammation 0.08-0.3 mg/kg/day IV/IM divided q6hr or q12hr Meningitis >6 weeks: 0.6 mg/kg/day IV divided q6hr for first 2-4 days of antibiotic therapy, starting 10-20 minutes before or simultaneously with first antibiotic dose Cerebral Edema Associated With Brain Tumor 1-2 mg/kg IV/IM once; maintenance: 1-1.5 mg/kg/day IV/IM divided q4-6hr; not to exceed 16 mg/day Spinal Cord Compression 2 mg/kg/day IV divided q6hr
Systemic fungal infections . Hypersensitivity to any component of this product, including sulfites
Mode of Action
Dexamethasone is a synthetic glucocorticoid which decreases inflammation by inhibiting the migration of leukocytes and reversal of increased capillary permeability. It suppresses normal immune response.
This product, like many other steroid formulations, is sensitive to heat. Therefore, it should not be autoclaved when it is desirable to sterilize the exterior of the vial. Following prolonged therapy, withdrawal of corticosteroids may result in symptoms of the corticosteroid withdrawal syndrome including fever, myalgia, arthralgia, and malaise. This may occur in patients even without evidence of adrenal insufficiency. There is an enhanced effect of corticosteroids in patients with hypothyroidism and in those with cirrhosis. Corticosteroids should be used cautiously in patients with ocular herpes simplex for fear of corneal perforation. The lowest possible dose of corticosteroid should be used to control the condition under treatment, and when reduction in dosage is possible, the reduction must be gradual. Psychic derangements may appear when corticosteroids are used, ranging from euphoria, insomnia, mood swings, personality changes, and severe depression to frank psychotic manifestations. Also, existing emotional instability or psychotic tendencies may be aggravated by corticosteroids. Aspirin should be used cautiously in conjunction with corticosteroids in hypoprothrombinemia. Steroids should be used with caution in nonspecific ulcerative colitis, if there is a probability of impending perforation, abscess, or other pyogenic infection, also in diverticulitis, fresh intestinal anastomoses, active or latent peptic ulcer, renal insufficiency, hypertension, osteoporosis, and myasthenia gravis. When large doses are given, some authorities advise that antacids be administered between meals to help to prevent peptic ulcer. Growth and development of infants and children on prolonged corticosteroid therapy should be carefully followed. Steroids may increase or decrease motility and number of spermatozoa in some patients. Phenytoin, phenobarbital, ephedrine, and rifampin may enhance the metabolic clearance of corticosteroids resulting in decreased blood levels and lessened physiologic activity, thus requiring adjustment in corticosteroid dosage. These interactions may interfere with dexamethasone suppression tests which should be interpreted with caution during administration of these drugs. When corticosteroids are administered concomitantly with potassium-depleting diuretics, patients should be observed closely for development of hypokalemia. Intra-articular injection of a corticosteroid may produce systemic as well as local effects. Lactation: Drug excreted in breast milk; not recommended
Acne,Adrenal suppression,Arrhythmia,Bradycardia,Cardiac arrest,Cataracts,Change in spermatogenesis,Delayed wound healing,Depression,Diabetes mellitus,Diaphoresis,Emotional instability,Erythema,Euphoria,Exophthalmos,GI perforation,Glaucoma,Glucose intolerance,Glucosuria,Hepatomegaly,Hypokalemic alkalosis,Increased intracranial pressure,Increased transaminases,Insomnia,Kaposi's sarcoma,Menstrual irregularity,Moon face,Myopathy,Neuritis,Osteoporosis,Peptic ulcer,Perianal pruritus,Petechia,Perianal pruritus,Pituitary adrenal axis suppression,Pseudotumor cerebri (on withdrawal),Psychosis,Pulmonary edema,Rash,Seizure,Spermatogenesis altered (increased or decreased),Ulcerative esophagitis,Urticaria,Vertigo,Weight gain
Pregnancy Category Note
Pregnancy Corticosteroids readily cross the placenta Adverse developmental outcomes including orofacial clefts (cleft lip with or without cleft palate), intrauterine growth restriction, and decreased birth weight have been reported with maternal use of corticosteroids during pregnancy Pregnancy testing is recommended for females of reproductive potential before initiating treatment Contraception Use effective contraception during treatment and for at least 1 month following final dose Infertility in males Steroids may increase or decrease motility and number of spermatozoa in some patients In animals, dexamethasone affects male spermatogenesis Lactation Systemically administered corticosteroids appear in human milk and could suppress growth, interfere with endogenous corticosteroid production, or cause other untoward effects Advise women not to breastfeed during treatment and for 2 weeks after the last dose
Increased risk of hypokalaemia when used concurrently with potassium-depleting drugs such as amphotericin B and loop diuretics. Reduces efficacy of isoniazid, salicylates, vaccines and toxoids. Increased activity of dexamethasone and cyclosporin when used together. Concurrent use with aspirin or ethanol may lead to increased GI side effects. Potentially Fatal: Reduced efficacy in combination with ephedrine, cholestyramine, phenytoin, phenobarbital and rifampicin.
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.