Gastrointestinal tract spasm, Intestinal hypermotility, Irritable bowel syndrome (IBS)
May be taken with or without food. May be taken before or after meals.
Oral Tablet/Syrup Gastrointestinal tract spasm Adult: 10-20 mg tid. Intramuscular Gastrointestinal tract spasm Adult: 20 mg 4 times a day given only for 1-2 days. Replace with oral therapy as soon as possible.
Oral Tablet/Syrup Gastrointestinal tract spasm Child: 2-12 yr: 10 mg tid; 6 mth-2 yr: 5-10 mg 3-4 times daily.
Intestinal obstruction; intestinal atony; myasthenia gravis; glaucoma; reflux oesophagitis; infants <6 mth; lactation.
Mode of Action
Dicycloverine HCl relieves smooth muscle spasm in the GI and urinary tract. This effect is partly due to antimuscarinic action and partly direct action on the smooth muscle.
Hepatic or renal disease, urinary retention, paralytic ileus, hyperthyroidism, hypertension, congestive heart failure, cardiac tachyarrhythmia, children, elderly, pregnancy.
Difficulty in accommodation, exacerbation of glaucoma; tachycardia, palpitations, arrhythmias; urinary retention; restlessness; confusion, excitement, hallucination and delirium. Potentially Fatal: Respiratory arrest in infants <10 wk.
Antagonise the effect of drugs that affect GI motility e.g. metoclopramide. Absorption affected by concurrent admin with antacids.
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