Introduction
Salol belongs to a group of medicines called fast-acting bronchodilators or “relievers”. It’s used to treat the symptoms of asthma and chronic obstructive pulmonary disease (COPD) such as coughing, wheezing and feeling short of breath.
You can take Salol with or without food. The dose will depend on your condition and how your respond to the medicine. Try to take it at the same time each day. It's important to keep taking this medicine until your doctor tells you not to. Use this medicine regularly to get the most benefit from it even if you feel well.
Salol is generally safe and effective but some common side effects include tremor, headache. fast heart rate, and muscle cramps. These side effects aren't often dangerous and they should gradually improve as your body gets used to this medicine. There are other, rarer, side effects and you should call your doctor straight away if you get chest pain, a very bad headache or very bad dizziness.
Before using Saloll, you should tell your doctor if you have high blood pressure, an overactive thyroid gland, a history of heart problems, diabetes or low levels of potassium in your blood to make sure it's safe. Also make sure your doctor knows if you're pregnant or breast-feeding before taking this medicine. Because this medicine can make you feel dizzy or shaky, don't drive, cycle or use tools or machinery until you feel better. And you shouldn't smoke. Smoking causes damage to your lungs and will make your condition worse.
Uses of Salol
- Asthma
- Chronic obstructive pulmonary disease (COPD)
Side effects of Salol
Common
- Headache
- Tremor
- Muscle cramp
How to use Salol
Check the label for directions before use. Shake the inhaler. While you are breathing in from mouth, press down on the inhaler one time to release the medication and hold your breath for 10 seconds. Repeat until you have inhaled the number of puffs as suggested by the doctor.Afterwards, rinse your mouth thoroughly with water and spit it out.
How Salol works
Salol is a bronchodilator. It works by relaxing the muscles in the airways and widens airways. This makes breathing easier.
What if you forget to take Salol?
If you miss a dose of Salol, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Indication
Acute severe asthma, Severe bronchospasm
Administration
Tablet/Syrup: Should be taken on an empty stomach. Take 1 hr before or 2 hr after meals.
Aerosol Metered-Dose Inhaler
Prime the inhaler before using for the first time and in cases where the inhaler has not been used for >2 weeks by releasing 4 “test sprays” into the air, away from the face
Patient instructions for administration
Shake well before each use
Breathe out fully through the mouth, expelling as much air from your lungs as possible; place the mouthpiece fully into the mouth, holding the inhaler in its upright position and close the lips around it
While breathing in deeply and slowly through the mouth, fully depress the top of the metal canister with your index finger
Hold your breath as long as possible, up to 10 seconds; before breathing out, remove the inhaler from your mouth and release your finger from the canister
If your physician has prescribed additional puffs, wait 1 minute, shake the inhaler again, and repeat steps listed above; replace the cap after use
Cleaning
To maintain proper use of this product, it is important that the mouthpiece be washed and dried thoroughly at least once a week
Keeping the plastic mouthpiece clean is very important to prevent medication buildup and blockage
The inhaler may cease to deliver medication if not properly cleaned and air dried thoroughly
If the mouthpiece becomes blocked, washing the mouthpiece will remove the blockage
Powder Metered-Dose Inhaler
Does NOT require priming
Do not use with a spacer or volume holding chamber
Cleaning
Keep clean and dry at all times
Never wash or put any part of inhaler in water
Routine maintenance not required
If the mouthpiece needs cleaning, gently wipe with a dry cloth or tissue as needed
Adult Dose
Oral
Acute bronchospasm
Adult: 2-4 mg 3 or 4 times daily, up to 8 mg 3 or 4 times daily.
As modified-release tab: 8 mg bid.
Not to exceed 32 mg/day
Elderly: 2 mg 3 or 4 times daily.
Inhalation
Acute bronchospasm, Intermittent episodes of asthma
Adult: As metered-dose aerosol or dry powd inhaler (90 or 100 mcg/actuation): 1 or 2 inhalations (1 ConviCap) as a single dose when required.
Not to exceed 12 inhalations/24 hr
Chronic maintenance or prophylactic therapy
Adult: As metered-dose aerosol or dry powd inhaler (90 or 100 mcg/actuation): 2 inhalations (1 ConviCap) 3-4 times daily. Max: 800 mcg daily.
Acute severe asthma
Adult: As metered-dose inhaler (100 mcg/actuation) via spacer device: Initially, 4-8 puffs inhaled every 20min for up to 4 hr and then 1-4hrly as required. Max: 10 inhalations.
Prophylaxis of exercise-induced bronchospasm
Adult: As metered-dose aerosol or dry powd inhaler (90 or 100 mcg/actuation): 2 inhalations (1 ConviCap) 10-15 min prior to exercise.
Nebuliser Solution
Severe bronchospasm
Adult: Via nebuliser: 2.5-5 mg, up to 4 times daily, alternatively, may be given continuously at a rate of 1-2 mg/hr.
Reconstitution: Dilute 0.5 mL of soln to a total of 3 mL w/ NaCl 0.9% to prepare a 2.5 mg dose.
Respirator Solution
0.5-1.0 ml should be diluted to final volume of 3-4 ml with normal saline for injection. The resulting solution is inhaled from a suitably driven nebulizer until aerosol generation ceases. Should take about 10 minutes.
Parenteral
Severe bronchospasm
Adult: IM/SC: 500 mcg (8 mcg/kg) and repeated 4 hrly as required.
Intravenous
Severe bronchospasm
Adult: As 50 mcg/mL soln: 250 mcg (4 mcg/kg) injected slowly. May be repeated if necessary.
As 10 mcg/mL soln: Usual rate of 3-20 mcg/min (0.3-2 mL/min), adjusted according to patient needs. Higher doses may be used in resp failure.
Reconstitution: Dilute 5 mL of soln w/ 500 mL NaCl or dextrose inj or other suitable diluents to provide a 10 mcg/mL soln.
Child Dose
Oral
Children
Acute bronchospasm
Tablet
Child: 2-6 yr 1-2 mg;
>6-12 yr 2 mg;
>12 yr 2-4 mg 3 or 4 times daily, up to 8 mg 3 or 4 times daily.
Syrup
2 - 6 years: 2.5 ml syrup, 3-4 times daily
6-12 years: 5 ml syrup, 3-4 times daily
Over 12 years: 5-10 ml syrup, 3-4 times daily (2-4 mg tablet, 3-4 times daily)
Inhalation
Acute bronchospasm
Child: 4-12 yr 1 inhalationas a single dose, may be increased to 2 inhalations as necessary. Max: 400 mcg daily.
Prophylaxis of exercise-induced bronchospasm
Child: 4-12 yr 1 inhalation 10-15 min prior to exercise.
Nebuliser Solution
Severe bronchospasm
Child> 4 years: Via nebuliser: 2.5-5 mg, up to 4 times daily, alternatively, may be given continuously at a rate of 1-2 mg/hr.
Reconstitution: Dilute 0.5 mL of soln to a total of 3 mL w/ NaCl 0.9% to prepare a 2.5 mg dose.
Respirator Solution
0.5-1.0 ml should be diluted to final volume of 3-4 ml with normal saline for injection. The resulting solution is inhaled from a suitably driven nebulizer until aerosol generation ceases. Should take about 10 minutes.
Parenteral
Severe bronchospasm
Child >12 years: IM/SC: 500 mcg (8 mcg/kg) and repeated 4 hrly as required.
Intravenous
Severe bronchospasm
Child >12 years: As 50 mcg/mL soln: 250 mcg (4 mcg/kg) injected slowly. May be repeated if necessary.
As 10 mcg/mL soln: Usual rate of 3-20 mcg/min (0.3-2 mL/min), adjusted according to patient needs. Higher doses may be used in resp failure.
Reconstitution: Dilute 5 mL of soln w/ 500 mL NaCl or dextrose inj or other suitable diluents to provide a 10 mcg/mL soln.
Contraindication
Salbuatmol inhaler is contraindicated in patients with a history of hypersensitivity to any of its components. Although intravenous Salbutamol, and occasionally Salbutamol tablets, is used in the management of premature labour uncomplicated by conditions such as placenta praevia, ante-partum haemorrhage or toxaemia of pregnancy, Salbutamol inhaler preparations are not appropriate for managing premature labour. Salbutamol preparation should not be used for threatened abortion during the first or second trimesters of pregnancy.
Mode of Action
Salbutamol is a direct-acting sympathomimetic with beta-adrenergic activity and selective action on ?2 receptors, producing bronchodilating effects. It also decreases uterine contractility.
Precaution
Hyperthyroidism, myocardial insufficiency, arrhythmias, susceptibility to QT-interval prolongation, HTN, DM, glaucoma, hypokalaemia, seizure disorder. Renal impairment. Elderly. Pregnancy and lactation. Monitoring Parameters Monitor BP, heart rate, electrolyte and fluid balance; glucose, lactate and K levels.
Lactation: Unknown whether drug is excreted in milk; not recommended
Side Effect
>10%
Tremor (20%),Nervousness in children aged 2-6 years (20%),Insomnia in children aged 6-12 years receiving 4-12 mg q12hr (11%)
1-10%
Nausea (10%),Fever (1.6-9%),Bronchospasm (8%),Vomiting (7%),Headache (4-7%),Dizziness (1-7%),Cough (5%),Allergic reactions (4%),Otitis media (3.3%),Epistaxis in children (3%),Increased appetite (3%),Urinary tract infection (3%),Dry mouth (<3%),Eructation or flatulence (<3%),Increased sweating (<3%),Pain (2.7%),Dyspepsia (1-2%),Hyperactivity (1-2%),Chills (<2%),Lymphadenopathy (<2%),Ocular pruritus (<2%),Sweating (<2%),Conjunctivitis in children aged 2-6 years (1%),Dysphonia (>1%),Flu syndrome,Nervousness
<1%
Epigastric pain,Epistaxis in adults,Hyperactivity in children
Frequency Not Defined
Adverse reactions such as hypertension, angina, vertigo, central nervous system stimulation, insomnia, headache, metabolic acidosis, and drying or irritation of oropharynx
Hypersensitivity,Hypokalemia,Increased blood glucose levels,Prolonged QT interval and ST-segment depression,Sleeplessness,Tachycardia (incidence varies with formulation)
Urticaria, angioedema, rash, bronchospasm, and oropharyngeal edema (rare)
Potentially Fatal: Potentially serious hypokalaemia after large doses.
Interaction
Diuretics, corticosteroids and xanthines may augment hypokalaemia. CV effects potentiated by MAOIs, TCAs, sympathomimetics. Increases absorption of sulfamethoxazole when used together. May markedly increase heart rate and BP when used with atomoxetine. Reduces serum levels of digoxin. Hypokalaemia induced by salbutamol increases the risk of digitalis toxicity. BP should be closely monitored if linezolid is used concurrently with salbutamol.