CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Rifabac. Please consult your doctor.
CONSULT YOUR DOCTOR
Rifabac may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Rifabac is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Rifabac does not usually affect your ability to drive.
SAFE IF PRESCRIBED
Rifabac is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Rifabac may not be needed in these patients. Please consult your doctor.
Rifabac should be used with caution in patients with severe liver disease. Dose adjustment of Rifabac may be needed. Please consult your doctor.
Rifabac is an antibiotic that treats hepatic encephalopathy, a condition in which the liver fails to remove harmful toxins from the blood, leading to brain damage. Symptoms include agitation, confusion, muscle problems, difficulty in speaking and sometimes, coma. Rifabac is also used to treat infectious diarrhea and irritable bowel syndrome with diarrhea (IBS-D) in adults and children. This medicine can be used alone or in combination with other medicines. It may be taken with or without food, preferably at the same time, each day. It should be used in the dose and duration as advised by the doctor. Take it at the same time each day to get the most benefit and you should keep on taking this medicine for as long as you are prescribed. Stopping it early may make the infection to come back and harder to treat. Some people may develop side effects like vomiting, headache, dizziness, and nausea. These side effects are usually temporary and go away during treatment as your body adjusts to the medicine. Consult your doctor if these side effects bother you or will not go away. Your urine may become reddish in color due to this medicine. But, it is normal and harmless. Before starting treatment with this medicine, you should tell your doctor if you are pregnant, breastfeeding or suffering from any liver, kidney or heart problems or if you are allergic to any medicine.
Uses of Rifabac
- Hepatic encephalopathy
Side effects of Rifabac
How to use Rifabac
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Rifabac may be taken with or without food, but it is better to take it at a fixed time.
How Rifabac works
Rifabac is an antibiotic. It works by killing the ammonia-producing bacteria in the digestive tract. This treats your infection and relieves symptoms of hepatic encephalopathy (agitation, confusion, muscle problems). This also helps reduce the recurrence of episodes of hepatic encephalopathy.
What if you forget to take Rifabac?
If you miss a dose of Rifabac, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
- Rifabac reduces the risk of overt hepatic encephalopathy (HE) recurrence in patients with liver disease.
- It may cause reddish discoloration of urine. This is normal and harmless.
- Stop taking Rifabac and inform your doctor if you have severe diarrhea during or after using Rifabac.
- Finish the full course of the medication, even if you feel better.
Traveler's diarrhea, irritable bowel syndrome
May take with or without food
Traveler's Diarrhea 200 mg PO q8hr for 3 days Hepatic Encephalopathy Maintenance of remission 550 mg PO q12hr Irritable Bowel Syndrome Indicated for irritable bowel syndrome with diarrhea (IBS-D) in adult men and women 550 mg PO q8hr for 14 days; recurrence of symptoms can be retreated with a 14 day treatment course, up to 2 times
Traveler's Diarrhea <12 years: Safety and efficacy not established >12 years: 200 mg PO q8hr for 3 days, with or without food
Contraindicated in patients with a hypersensitivity to Rifaximin or to any of the rifamycin antimicrobial agents, or any components of this product.
Mode of Action
Antimicrobial action is a result of binding to the beta-subunit of bacterial DNA-dependent RNA polymerase, resulting in inhibition of transcription. Hepatic encephalopathy: Inhibits growth of enteric ammonia-producing bacteria to indirectly reduce serum ammonia level. Irritable bowel syndrome with diarrhea (off-label): Inhibits growth of enteric bacteria to reduce gas production.
Rifaximin is not found to be effective in patients with diarrhea complicated by fever and/or blood in the stools. Rifaximin therapy should be discontinued if diarrhea symptoms get worse or persist for more than 24-48 hours and an alternative antibiotic therapy should be considered. Pseudomembranous colitis has been reported with nearly all antibacterial agents and may range in severity from mild to life-threatening. Therefore, it is important to consider this diagnosis in patients who present with diarrhea subsequent to the administration of antibacterial agents. Lactation: Do not use if nursing or do not nurse
>10% Flatulence (11%) 1-10% Headache (10%),Rectal tenesmus (7%),Abdominal pain (7%),Defecation urgency (6%),Nausea (5%),Constipation (4%),Pyrexia (3%),Vomiting (2%) Frequency Not Defined Hypersensitivity reactions (including allergic dermatitis),Pruritus,Rash
Although in vitro studies demonstrated the potential of rifaximin to interact with cytochrome P450 (CYP3A4), a clinical drug-drug interaction study demonstrated that rifaximin did not significantly affect the pharmacokinetics of midazolam. An additional clinical drug-drug interaction study showed no effect of rifaximin on the presystemic metabolism of an oral contraceptive containing ethinyl estradiol and norgestimate. Therefore, clinical interactions with drugs metabolized by human cytochrome P450 isozymes are not expected.
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.