Introduction
Promex 100 is an antiparasitic medication. It is used in the treatment of worm infections. It works by killing the worms and this treats your infection.
Promex 100 should be used in the dose and duration as advised by your doctor. It should be taken with food, preferably at a fixed time. Avoid skipping any doses and finish the full course of treatment even if you feel better. Do not take a double dose to make up for a missed dose. Simply take the next dose as planned.
Some people may experience stomach pain as a side effect of this medicine. Please consult your doctor if these side effects persist for a longer duration. You may be monitored with blood tests and liver function tests throughout your treatment.
Side effects of Promex 100
How to use Promex 100
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Promex 100 may be taken with or without food, but it is better to take it at a fixed time.
How Promex 100 works
Promex 100 affects the permeability of the cell membrane thereby killing the worms.
Indication
Enterobiasis, Hookworm infections, Filariasis, Toxocariasis, Ascarisis, Trichuriasis, Trichostrongyliasis, Trichinellosis, Dracunculiasis
Administration
May be taken with or without food. May be swallowed whole, chewed, or crushed and mixed with food
Adult Dose
Oral
Adults:
Enterobiasis :
A single tablet( 100 mg) or 1 teaspoonful (5 ml) of the suspension.
If cure is not achieved 3 wk after treatment, a second course of treatment is advised
Ascariasis, Ancylostomiasis, Trichuriasis :
100 mg bid for 3 consecutive days or 500 mg as single dose or 1 teaspoonful (5 ml) bid for 3 consecutive days.
If cure is not achieved 3 wk after treatment, a second course of treatment is advised
Taeniasis & strongyloidiasis :
100 mg bid for 3 consecutive days
If cure is not achieved 3 wk after treatment, a second course of treatment is advised
Child Dose
Oral
Enterobiasis
Child: >2
A single tablet( 100 mg) or 1 teaspoonful (5 ml) of the suspension.
If cure is not achieved 3 wk after treatment, a second course of treatment is advised
Ascariasis, Ancylostomiasis, Trichuriasis :
Child: >1 yr
100 mg bid for 3 consecutive days or 500 mg as single dose or 1 teaspoonful (5 ml) bid for 3 consecutive days.
If cure is not achieved 3 wk after treatment, a second course of treatment is advised
Taeniasis & strongyloidiasis :
100 mg bid for 3 consecutive days
If cure is not achieved 3 wk after treatment, a second course of treatment is advised
Contraindication
Hypersensitivity. Infants and children <2 yr.
Mode of Action
Mebendazole inhibits formation of helminth microtubules. It selectively and irreversibly blocks the uptake of glucose and other nutrients in susceptible helminths, resulting in endogenous depletion of glycogen stores in the helminth.
Precaution
Hepatic impairment. Childn. Pregnancy and lactation. Monitoring Parameters Periodic assessment of haematologic, hepatic, and renal function; check for helminth ova in faeces w/in 3-4 wk following the initial therapy.
Lactation: Excretion in breast milk unknown; use caution
Side Effect
Transient diarrhoea, abdominal pain, nausea, vomiting, headache, tinnitus, numbness, fever, alopecia, rash, pruritus, urticaria, angioedema, flushing, hiccups, cough, weakness, drowsiness, chills, hypotension, seizures, transient abnormalities in LFT (e.g. increased serum concentrations of aminotransferases, glutamyltransferase alkaline phosphatase, and/or bilirubin), hepatitis, increased BUN, decreased Hb concentration and/or hematocrit, leucopenia, eosinophilia, haematuria, cylindruria, migration of roundworms through the mouth and nose.
Potentially Fatal: Myelosuppression, manifested as neutropenia (including agranulocytosis) and/or thrombocytopenia.
Interaction
Decreased plasma concentrations w/ carbamazepine and phenytoin. Increased plasma concentrations w/ cimetidine.