Pericard Plus1.25/4 may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Pericard Plus1.25/4 is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
SAFE IF PRESCRIBED
Pericard Plus1.25/4 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Pericard Plus1.25/4 may cause side effects which could affect your ability to drive. Pericard Plus1.25/4 usually does not affect alertness but dizziness or weakness due to low blood pressure may occur in some patients. This may affect your driving ability.
Pericard Plus1.25/4 should be used with caution in patients with kidney disease. Dose adjustment of Pericard Plus1.25/4 may be needed. Please consult your doctor. Caution should be advised in patients with renal impairment.
Pericard Plus1.25/4 should be used with caution in patients with liver disease. Dose adjustment of Pericard Plus1.25/4 may be needed. Please consult your doctor.
Pericard Plus1.25/4 is a medicine used to treat hypertension (high blood pressure). It is a combination of two medicines that helps to control blood pressure when a single medication is not effective. It helps to reduce the chances of any future heart attack and stroke. Pericard Plus1.25/4 should be taken on empty stomach, preferably in the morning to avoid frequent urination at night. Keep taking it for as long as advised by your doctor. Even if you feel well, do not stop this medicine on your own because high blood pressure often has no symptoms. If you stop taking it, your condition may get worse. Keeping active with regular exercise, reducing your weight and eating a healthy diet will also help control your blood pressure. Follow your doctor's advice while taking this medicine. Nausea, taste change, diarrhea, and indigestion are some common side effects of this medicine. Consult your doctor If any of these bother you, or get worse, or do not go away. Let your doctor know about cough or throat irritation that does not go away. Drink plenty of fluids while taking medicine to overcome muscle weakness, dry mouth, and extreme thirst. If dizziness happens, rise slowly from sitting position or avoid driving. Before taking it, let your doctor know if you have any liver or kidney problems. Pregnant or breastfeeding women should also consult their doctor for advice before taking this medicine. You also need to tell your doctor what other medicines you are taking especially those used to treat high blood pressure or heart conditions. You should have your blood pressure, kidney function and the levels of salts such as potassium checked regularly to make sure that this medicine is working properly.
Uses of Pericard Plus1.25/4
- Hypertension (high blood pressure)
Side effects of Pericard Plus1.25/4
- Stomach pain
- Altered vision
- Ringing in ear
- Allergic reaction
- Skin rash
How to use Pericard Plus1.25/4
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Pericard Plus1.25/4 is to be taken empty stomach.
How Pericard Plus1.25/4 works
Pericard Plus1.25/4 is a combination of two medicines: Perindopril and indapamide which lower blood pressure effectively. Perindopril is an angiotensin-converting enzyme (ACE) inhibitor. It works by reducing stress on the heart and relaxing blood vessels so that blood flows more smoothly and the heart can pump blood more efficiently. Indapamide is a diuretic that removes extra water and certain electrolytes from the body. Over time it also relaxes blood vessels and improves blood flow.
- You have been prescribed Pericard Plus1.25/4 for the treatment of high blood pressure.
- It also lowers your risk of stroke and heart attack.
- Take it in the morning with breakfast, to avoid getting up at night to urinate.
- Pericard Plus1.25/4 may cause dizziness or sleepiness. Don't drive or do anything requiring concentration until you know how it affects you.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
- Inform you doctor about any cough, or throat irritation that doesn't go away.
- Pericard Plus1.25/4 may cause dehydration. Drink plenty of fluids and Inform your doctor if you develop extreme thirst, muscle weakness or very dry mouth.
- Your doctor may regularly monitor your blood pressure, kidney function and the levels of salts such as potassium in your blood while you are taking this medicine.
- Do not take Pericard Plus1.25/4 if you’re pregnant or planning pregnancy. It can cause birth defects or be fatal to your unborn baby.
Oral Hypertension Adult: 1 tab once daily in the morning.
Renal impairment: CrCl (ml/min) Dosage Recommendation <30 Avoid use. 30-60 Dose adjustment may be needed
Hypersensitivity. Severe renal impairment (CrCl <30 ml/min), hypokalaemia, severe hepatic impairment or hepatic encephalopathy, history of angioedema associated with treatment with an ACE inhibitor, children. Dialysis patients or patients with untreated decompensated heart failure. Hereditary/idiopathic angioneurotic oedema. Pregnancy and lactation.
Mode of Action
Perindopril is an ACE inhibitor, which acts by inhibiting the conversion of angiotensin I to angiotensin II, reducing the activity of the sympathetic nervous system and inhibiting enzyme kininase, which is involved in the conversion of bradykinin and other substances. Indapamide is a sulfonamide derivative with an indole ring. It inhibits the reabsorption of sodium in the cortical dilution segment, thus increasing urinary output, resulting in an antihypertensive effect.
Impaired renal function, risk of hypotension and electrolyte imbalance. Regular monitoring of renal function and plasma levels of potassium are recommended. Blood glucose levels should be monitored in diabetic patients especially in those with low serum potassium levels. Increased risk of neutropenia/agranulocytosis in immunosuppressed patients. Treatment should be discontinued immediately if there is angioneurotic oedema of the face, extremities, lips, tongue, glottis and/or larynx.
Dry cough, headache, bradycardia, dizziness, asthenia, hypokalaemia and orthostatic hypotension. GI effects such as constipation, dry mouth, nausea, epigastric pain, anorexia, abdominal pain and taste disturbance.
Additive effect with other antihypertensive agents and diuretics. Increased chance of hypokalaemia with corticosteroids, corticotropin and amphotericin. Potentially Fatal: Increased risk of lithium toxicity. Hypokalaemia enhances digitalis toxicity with cardiac gycosides.
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.