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ফার্মেসীর জন্য পাইকারি দামে ঔষধ কিনতে রেজিস্টেশন করুন
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Sefety Advices
It is not known whether it is safe to consume alcohol with Oxifyl CR. Please consult your doctor.
Oxifyl CR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Oxifyl CR is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Oxifyl CR may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Oxifyl CR should be used with caution in patients with kidney disease. Dose adjustment of Oxifyl CR may be needed. Please consult your doctor.
There is limited information available on the use of Oxifyl CR in patients with liver disease. Please consult your doctor.
Medical Overview
Oxifyl CR is used to treat peripheral vascular disease (poor circulation to the arms and legs) and intermittent claudication (pain on walking or at rest caused by poor circulation to the legs). It works by increasing the blood flow to the arms and legs. Oxifyl CR reduces cramping in the legs that occur on walking in such patients. It also has beneficial effects in alcohol-related liver damage. This medicine should be taken regularly as advised by the doctor. You should take it with food and at a fixed time. You should never stop it abruptly without consulting the doctor. This medicine is only one part of a treatment program which should also include a healthy diet, regular exercise, and smoking cessation. It may cause side effects like nausea, vomiting, diarrhea, headache, flushing (sense of warmth in the face, ears, neck, and trunk), and weakness. This medicine may not be suitable for some people. You must inform the doctor if you are suffering from any liver or kidney disease. Also, let your doctor know about all the other medications that you are using regularly. This medicine is not usually recommended during pregnancy or breastfeeding, so always consult your doctor before taking it.
Uses of Oxifyl CR
  • Peripheral vascular disease
  • Intermittent claudication
Side effects of Oxifyl CR
  • Bloating
  • Diarrhea
  • Flushing (sense of warmth in the face, ears, neck and trunk)
  • Headache
  • Heartburn
  • Lightheadedness
  • Nausea
  • Stomach discomfort
  • Vomiting
  • Weakness
How to use Oxifyl CR
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Oxifyl CR is to be taken with food.
How Oxifyl CR works
Oxifyl CR is a peripheral vasodilator. It works by decreasing the thickness (viscosity) of blood, allowing it to pass more easily through the blood vessels. This effect is beneficial in peripheral vascular disease, where the blood vessels in the arms and legs are narrowed.
What if you forget to take Oxifyl CR?
If you miss a dose of Oxifyl CR, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
  • Take it as per dose and duration suggested by your doctor.
  • Take it with or without food.
  • Do not drive or perform activities that require mental focus until you know how Trental 400 Tablet ER affects you.
  • Your doctor may get regular blood tests done to monitor liver function while taking this medicine.
  • Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Brief Description
Peripheral vascular disease
Should be taken with food.
Adult Dose
Oral Peripheral vascular disease Adult: As modified-release formulation: 400 mg tid (normally for at least 8 wk) May reduce to 400 mg bid if GI or CNS adverse effects occur. Intermittent Claudication 400 mg PO q8hr Recommended duration of treatment: >8 weeks Hepatic impairment: Dose reduction may be needed in severe impairment.
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment: Moderate impairment (CrCl about 60 ml/min): 400 mg bid; Severe impairment (CrCl about 20 ml/min): 400 mg once daily; may reduce further to 400 mg once every other day if needed.
Previous hypersensitivity reactions to xanthine-related products e.g. caffeine, theophylline and theobromine. Recent cerebral and/or retinal haemorrhage. Porphyria.
Mode of Action
Pentoxifylline reduces blood viscosity by increasing deformability of leukocytes and erythrocytes; and decreasing neutrophil adhesion/activation. It also improves microcirculation and peripheral tissue oxygenation through better blood flow. It has also been used in cerebrovascular disorders.
Avoid use in patients with severe cardiac arrhythmias or acute MI. Caution when used in patients with ischaemic heart disease or hypotension. Impaired renal or hepatic function. Start at lower dose in elderly; safety and efficacy not established in children. Tablets should not be chewed, crushed or broken; swallow whole. Pregnancy, lactation. Lactation: Drug excreted in breast milk; discontinue therapy, or do not nurse
Side Effect
1-10% Nausea,Vomiting <1% Angina,Anaphylaxis,Anorexia,Aplastic anemia,Pancytopenia,Conjunctivitis,Angioedema,Aseptic meningitis,Chest pain,Leukemia,Leukopenia,Cholecystitis,Hepatitis,Seizure,Scotoma,Thrombocytopenia,Increased live enzyme Potentially Fatal: Fatal haemorrhage (cerebral and GI tract); anaphylactoid reaction.
Concurrent use with ciprofloxacin may increase the adverse effect of pentoxifylline. Concurrent use may increase serum levels of theophylline derivatives. Potentially Fatal: May increase risk of adverse effect when used with ketorolac.
ফার্মেসীর জন্য পাইকারি দামে ঔষধ কিনতে রেজিস্টেশন করুন
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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.